An experimental new publishing platform. Browse the latest research.

Spontaneous Raman spectroscopy detects chemical perturbation of protein structure

MSA-based pLMs encode evolutionary distance but don’t reliably exploit it

Efficient GFP variant design with a simple neural network ensemble

Mapping the spectrum of archaeal protein sequence–structure relationships

G–P Atlas\: A neural network framework for mapping genotypes to many phenotypes

Do protein language models understand evolution? Mixed evidence from ancestral sequences and ESM2

Epistasis and deep learning in quantitative genetics

Predicting peptides from tick salivary glands that suppress host detection

How confident should we be in potential targets of tick protease inhibitors predicted by AlphaFold-Multimer?

Compound 48/80 is toxic in HMC1.2 and RBL-2H3 cells

Paired residue prediction dependencies in ESM2

Predicting antimicrobial resistance phenotypes across 7,000 *E. coli* genomes

Structure-based protein clustering sometimes, but not always, provides insight into protein function

Comparative phylogenomic analysis of chelicerates points to gene families associated with long-term suppression of host detection

Early update on Arcadia publishing 2.0\: Scientists are in charge, speed is an issue

Leveraging evolution to identify novel organismal models of human biology